Abstract: Objective To explore the change of blood coagulation function and the clinical diagnosis and treatment for early deep venous thrombosis in patients with fracture after operation.Methods A total of 80 fracture patients were divided into control group and observation group,40 cases in each group.Blood coagulation indexes and platelet count before and 1,3,5 and 7 days after the operation were compared between two groups.Results The PT,TT,and APFT increased significantly at 1,3,5 and 7 days after surgery in all the patients (P ＜ 0.05).After operation,the PLT decreased significantly (P ＜ 0.05).After treatment,the indexes of blood coagulation function in the observation group significantly decreased (P ＜ 0.05).Conclusion After the operation,the patients with fracture had venous relaxation and high blood coagulation status caused by anesthesia and other reasons.