Abstract: Objective To explore the significance of expressions of glutamate transporters and γ-aminobutyric acid transporters in the rat model with cerebral ischemia.Methods The detections of the expressions of glutamate transporter-1 (EAAC-1) and γ-aminobutyric acid transporter-1 (GAT-1) in models with ischemia in vivo and hypoxia in vitro were performed by immunofluorescence,Westen-blot and real-time polymerase chain reaction (RT-PCR) methods.Results The expression of EAAC1 was reduced in the cerebrum of focal cerebral ischemic MACO rat model as well as in primary neurons cultured under hypoxia.The expression of GAT1 was elevated.Conclusion EAAC1 expression decreases while GAT1 expression increases under condition of cerebral ischemia and anoxia.