Abstract: Objective To explore clinical effect of edaravone and breviscapine injection and its influence on neurologic impairment and life quality of patients with ischemic stroke.Methods A total of 148 patients were randomly divided into observation group (74 cases) and control group (74 cases).Patients in observation group were treated with edaravone and breviscapine injection,while those in the control group were treated with edaravone injection.The clinical efficacy,neurologic impairment and quality of life were compared.Results After treatment,the total response rate was 94.59％ in observation group,which was significantly higher than 81.08％ in the control group (P ＜0.05).The NIHSS scores of observation group were significantly better than that of control group (P ＜0.05).The serum NSE,S-100β and MMP-9 levels of observation group after 7 d treatment were significantly lower than that of the control group (P ＜ 0.05),and the serum MMP-9 level of observation group after 14 d was significantly lower than that of the control group (P ＜ 0.05).The SF36 quality of life scores of observation group were significantly better than that of control group (P ＜0.05).Conclusion The treatment of edaravone and breviscapine for patients with ischemic stroke has an obvious curative effect,and it is worthy of further promotion in clinic.