Abstract: Objective To analyze the correlation between PLCE1,RFT2 expressions and esophageal squamous cell carcinoma and their effects on prognosis.Methods Ninety esophageal cancer patients were selected.Immunohistochemical SP method was used to detect PLCE1 and RFT2 expressions in esophageal squamous cell carcinoma and adjacent normal esophageal tissues,and correlation between PLCE1,RFT2 expressions and clinicopathological features as well as relationship between PLCE1 and RFT2 were analyzed.Results Positive rates of PLCE1 and RFT2 in esophageal squamous cell tissue and normal esophageal tissues were 86.67％,16.00％ and 80.00％,18.00％ respectively,and there were significant differences (P ＜ 0.05).PLCE1 and RFT2 expressions were correlated with esophageal clinical T stage,lymph node metastasis and the longest diameter (P ＜ 0.05).PLCE1 expression was positively correlated with RFT2 expression in esophageal cancer tissue (rs =6.544 8,P ＜ 0.05).Conclusion PLCE1 and RFT2 are highly expressed in esophageal squamous cell carcinoma,and are closely correlated with tumor maximum diameter,lymph node metastasis and clinical stages.