Abstract: Objective To explore the effect of SSRI anti depression drugs combined with conventional drugs for cerebral vascular disease on treatment of patients with post stroke depression (PSD).Methods A total of 88 patients with PSD were randomly divided into the observation group and the control group,44 cases in each group.The control group was treated with conventional drugs for cerebral vascular disease,while the observation group was treated with paroxetine on the basis of the control groups.Clinical effect,the Hamilton depression scale (HAMD),neurological deficit score (NIHSS),cognitive function (MMSE) score and Barthel Index (BI) before and after treatments were compared between two groups.Results The total effective rate of observation group was 93.18％,which was significantly higher than 70.45％ of the control group (P ＜ 0.05).After treatment,the HAMD and the NIHSS scores were significantly lower than those before treatment in both groups,and the HAMD and the NIHSS scores in the observation group were significantly lower than those in the control group (P ＜ 0.05).After treatment,the scores of MMSE and BI were significantly higher than those before treatment in both groups,and the scores of MMSE and BI in the observation group were significantly higher than those in the control group (P ＜ 0.05).In the observation group,the incidence rate of adverse reactions was 6.82％.There were no adverse reactions in the control group.Conclusion Paroxetine combined with conventional drugs for cerebral vascular disease can improve the depressive syndromes of patients with PSD and promote the rehabilitations of nerve function,cognitive function and ability of daily living.