抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响

Effect of hepatic lesion caused by anti-tuberculosis drugs on serum levels of TNF-α, CG and CA-199 in elderly patients with pulmonary tuberculosis

摘要: 目的探讨抗结核药物肝损害对老年肺结核患者外周血肿瘤坏死因子-α (TNF-α)、甘胆酸(CG)及糖类抗原199(CA-199)水平的影响及与肝损害相关指标的相关性.方法 34例因服用抗结核药物出现药物肝损害肺结核患者设为观察组,32例老年健康人群作为对照组.结果观察组患者血清中TBIL、ALT及ALP水平显著高于对照组(P＜0.05);观察组患者血清中TNF-α、CG及CA-199水平显著高于对照组(P＜0.05).观察组患者血清中TNF-α、CG及CA-199水平与ALT均呈正相关(P＜0.05).结论抗结核药物肝损害可促进老年肺结核患者血清中TNF-α、CG及CA-199的表达.