非酒精性脂肪肝患者血清TNF-α、IL-6水平变化及其与胰岛素抵抗的相关性

Changes of serum tumor necrosis factor-α and interlukin-6 levels in patients with non-alcoholic fatty liver and its correlation with insulin resistance

摘要: 目的探讨非酒精性脂肪肝(NAFL)患者血清肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)的水平变化及其与胰岛素抵抗的相关性.方法选取39例NAFL患者为NAFL组,另选取同期健康体检者30例为对照组.比较2组空腹血糖(FBG)、胰岛索抵抗指数(HOMA-IR)、IL-6及TNF-α水平变化,分析HOMA-IR与血清IL-6和TNF-α水平的关系.结果 NAFL组的FBG、HOMA-IR、IL-6及TNF-α水平高于对照组,差异有统计学意义(P＜0.05,P＜0.01).Pearson相关性分析结果显示,HOMA-IR与IL-6、TNF-α具有显著正相关(r=0.649,0.724,P＜0.01).结论 NAFL患者血清IL-6和TNF-α水平显著升高,且与胰岛素抵抗关系密切.