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尿素乳膏护理干预索拉非尼相关手足皮肤反应随机对照研究

Randomized controlled trial of nurse intervention of urea-based cream on sorafenib-associated hand-foot skin reactions of patients

    摘要
  • 摘要: 目的：评价尿素乳膏（UBC）护理干预索拉非尼治疗肝细胞癌（HCC）所诱导手足皮肤反应（HFSR）的效果。方法202例进展 HCC 患者，随机分为2组各101例，尿素乳膏组采取10％尿素乳膏涂抹手脚一日3次加基础护理，对照组采取单纯基础护理。护理干预12周，每2周观察 HFSR 发生情况，一旦发生 HFSR 患者允许应用任何乳膏包括尿素乳膏。结果护理干预结束时，尿素乳膏组48．5％（49／101）的患者发生 HFSR，显著低于基础护理组的69．3％；2级以上 HFSR 发生者占19．8％（20／101），明显低于基础护理组35．6％（36／101）。尿素乳膏组患者首次发生 HFSR 的中位时间是基础护理组的1．63倍，尿素乳膏不影响索拉非尼治疗剂量调整、临床反应和疾病控制。结论尿素乳膏护理干预可降低 HCC 患者接受索拉非尼治疗时 HFSR 发生，减轻 HFSR 发生程度，延长首次 HFSR 发生时间，改善服用索拉非尼治疗患者的生活质量。

     

    Abstract: ABSTRACT:Objective To assess the effect of nurse intervention of urea-based cream (UBC)on sorafenib-induced hand-foot skin reaction (HFSR)in patients with advanced hepato-cellular carcinoma(HCC).Methods 202 advanced HCC patients were randomly divided into 2 groups.101 patients in the urea-based cream group were applied with 10% UBC three times dai-ly and best nursing while 110 patients in the control group were applied basic nursing alone.The treatment lasted for 12 weeks.HFSR was assessed every 2 weeks.Once HFSR occurred,patients were allowed any cream,including UBC.Results After the nursing,the incident rate of HFSR and incidence of grade ≥2 HFSR in the UBC group were lower that than in the BNC group.The Median time to first occurrence of HFSR was 1.63 times of UBC group.UBC did not affect the adjustment of sorafenib dose,response or disease control.Conclusion UBC nurse intervention of advanced HCC patients could reduce HFSR rate,extend the time of first occurrence of HFSR and improve the quality of life of patients.

     

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