Abstract: Obj ective To compare the difference of therapeutic efficacy of autologous and allogenic tendon for reconstruction of the ligaments of the lateral ankle by minimally invasive trans-plantation.Methods A total of 70 patients with reconstruction of the ligaments of the lateral ankle by minimally invasive transplantation were selected and divided into autologous group (36 cases)and allogenic group (34 cases).Patients of 2 groups were performed with minimally invasive transplan-tation for reconstruction of the ligaments of the lateral ankle.Autologous group adopted semitendi-nosus tendon of the inside of ipsilateral limb for transplantation and allogenic group adopted allograft ligaments.The same rehabilitation training was given for 2 groups after transplantation.Results The time of transplantation in autologous group was significantly longer than allogenic group (P<0 .0 1 )but the time of fever and wound healing of autologous group was shorter than allogenic group (P<0.05,or P<0.01).The score of ankle and exopodal,slant angle and migration distance of astragalus significantly improved (P<0.01),but there was no significant difference (P>0.05). After 2 years of follow up,the rate of good efficacy of autologous group was 74.29%and allogenic group was 68 .75%,and there was no significant difference between 2 groups (P>0 .05 ).Conclu-sion Either Autologous tendon or allogenic tendon has advantages and disadvantages in reconstruc-tion of the ligaments of the lateral ankle by minimally invasive transplantation,the operation should be selected according to the condition of the patients.