Abstract: Obj ective To explore the significance of serum lipoprotein and high sensitivity C-reactive protein (hs-CRP)level for the patients with type 2 diabetic nephropathy.Methods 174 patients with type 2 diabetic mellitus were divided into diabetic mellitus group,early diabetic nephropathy group and clinical diabetic nephropathy group,according to the urinary albumin excre-tion rate (UAER).60 healthy individuals were chosen as control group.Lipoprotein (α)Lp(α), high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C)and hs-CRP were detected,and the results were analyzed statistically.Results The level of Lp (α), hs-CRP were significantly higher in patients with diabetic mellitus than those in control group (P<0.05).Among the three groups with diabetic mellitus,the level of Lp(α)and hs-CRP got progres-sively significant higher with the increase of UAER (P<0 .05 )whereas the level of HDL-C and LDL-C did not find significant difference(P>0 .05 ).There were linear positive correlation between Lp(α),hs-CRP and UAER levels(r= 0.8069,0.8989).Conclusion Lp(α),hs-CRP levels may be related to the progression of diabetic nephropathy,and their detection had important clinical sig-nificance in early diagnosis and prognostic evaluation of type 2 diabetic nephropathy.