Abstract: Obj ective To observe and analyze the curative effect of large dose shock therapy of calcitriol on the treatment of the patients with end-stage renal disease (ESRD)complicated with secondary hyperparathyroidism (SHPT).Methods 60 patients with ESRD complicated with mod-erate or severe SHPT were selected as the research obj ects and randomly divided into the observation group and the control group,30 cases in each group.The patients in the observation group were treated with large dose shock therapy of calcitriol,while the patients in the control group were treated with routine dose therapy of calcitriol.The serum levels of calcium,phosphorus,parathy-roid hormone (PTH),hemoglobin (Hb)and hematocrit (HCT)of the patients in the two groups before and after the treatment were detected.The improvements of the skin itching of the patients were evaluated.Results The serum PTH level and the serum phosphorus levels of the patients in the two groups after the treatment were significantly lower than those before the treatment (P <0 .05 ),and the serum PTH level and the serum phosphorus levels of the patients in the observation group after the treatment were significantly lower than those in the control group (P<0 .05 ).The serum calcium level of the patients in the two groups after the treatment were significantly higher than that before the treatment (P<0 .0 5 ),and the serum calcium level of the patients in the observation group after the treatment were significantly higher than that in the control group (P<0 .05 ).The clinical efficacy in improving skin itching of the patients in the two groups were 90%and 40%,the clinical efficiency of the observation group was significantly higher than that of the control group (P<0 .05 ).Meanwhile,the proportion of the patients with the curative ef-fect of“significant”in the observation group was significantly higher than that in control group (P<0 .05 ).Hb and HCT levels of the patients in the two groups after the treatment were signif-icantly higher than those before the treatment (P<0 .05 ),and Hb and HCT levels of the patients in the observation group after the treatment were significantly higher than those in the control group (P<0 .05 ).Conclusion Application of large doses shock therapy of calcitriol in the treat-ment of ESRD complicated with SHPT can rectify the imbalance calcium and phosphorus metabolism of the patients rapidly,reduced the serum PTH level of the patients significantly,and relieve significantly the symptoms of skin itching or anemia of the patients.