Abstract: Objective To explore early diagnosis of early renal injury in pregnancy patients with hypertensive disorder complicating pregnancy(HDCP)by detection of serum cystain C(Cys C)and urine microalbumin(mALB).Methods A total of 150 pregnant women with HDCP were in the study group and 147 normal pregnant women were in control group.The pregnant women in study group were further divided into gestational hypertension group (60 pregnant women),mild preeclampsia group(51 pregnant women)and severe preeclampsia group (39 pregnant women )ac-cording to severity of the disease;The levels of Cys C,BUN,Scr and microalbumin(mALB)were detected.Results The levels of Cys C,BUN,Scr and mALB in study group were significantly higher than those in control group(P <0.05).The difference in levels of BUN and Scr was not statistically significant (P >0.05).The levels of CysC and mALB were statistically significant be-tween the gestational hypertension group and the mild preeclampsia group.The difference in levels of BUN,Scr,Cys C and mALB was statistically significant between the mild preeclampsia group and the severe preeclampsia group (P <0.05).The difference was significant in close positive cor-rection between the level of Cys C and mALB (r =0.671,P <0.05).Conclusion The increas-ing levels of CysC and mALB cause the worsening of the diseases.It is helpful to diagnose early re-nal injury of HDCP by combinative detection of serum Cys C and urine mALB.