检测血清超敏C反应蛋白在原发性高血压中的临床意义

陈小紫; 张宇云; 王波

doi:10.7619/jcmp.201416050

检测血清超敏C反应蛋白在原发性高血压中的临床意义

1.
海南省海口市第三人民医院心血管内科，海南海口，571100;
2.
海南省海口市中医医院心电图科，海南海口，571000

基金项目: 中国高校医学期刊临床专项资金

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- 发布日期: 2014-09-10

Clinical significance of detection of serum high sensitivity C-reactive protein of patients with primary hypertension

摘要

摘要: 目的：探讨原发性高血压患者检测血清超敏 C 反应蛋白（hs-CPR）水平的临床意义。方法选择原发性高血压患者152例，按高血压分级分为3组，嘱予低盐低脂饮食、适当锻炼等生活调理，给予常规降压治疗。观察半年，对观察期前后的hs-CPR水平进行对比，并与健康人群进行对比。结果观察期前后高血压组血清hs-CRP水平显著高于健康人群组（P ＜0．01）；入组时高血压2级、3级组血清 hs-CRP 水平显著高于高血压1级组（P ＜0．05）。观察期满后，高血压1级、2级、3级组血清 hs-CRP 水平显著低于各自入组时（P ＜0．05）；高血压2级、3级组血清 hs-CRP 水平显著高于高血压1级组（P ＜0．05）。结论原发性高血压患者具有明显增高的血清 hs-CPR 水平，血清 hs-CPR 与高血压的发生强烈相关。有效控制血压可明显降低其水平。
- 原发性高血压 /
- 药物治疗 /
- 超敏C反应蛋白 /
- 炎症反应
Abstract: Objective To investigate clinical significance of detection of serum high sensitiv-ity C-reactive protein (hs-CPR)of patients with primary hypertension.Methods A total of 152 patients with primary hypertension were divided into 3 groups according to the classification of hy-pertension.All patients were suggested to have low-salt and low-fat diet and proper physical exercise and received antihypertensive therapy.After half a year,hs-CPR levels before and after observation period were analyzed and compared with healthy people.Results Levels of hs-CRP before and after observation period were higher than that of healthy people (P <0.01).The hs-CRP levels of level 2 and level 3 of hypertension were obviously higher than level 1 of hypertension before grouping(P <0.05).After observation period,hs-CRP levels of level 1,level 2 and level 3 of hypertension were significantly lower than that before grouping in each group (P <0.05)while level 2 and level 3 were markedly higher than that of level 1 (P <0.05).Conclusion Primary hypertension has ob-viously increased hs-CRP and hs-CRP,so they have a strong relationship with the occurrence of hy-pertension.Therefore,effective control of blood pressure can obviously reduce the hs-CRP level.
- primary hypertension /
- drug therapy /
- hs-CRP /
- inflammatory response

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检测血清超敏C反应蛋白在原发性高血压中的临床意义

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Clinical significance of detection of serum high sensitivity C-reactive protein of patients with primary hypertension

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