Abstract: Objective To study effects of doxophylline of different administration methods on weaning time of acute exacerbation of chronic obstructive pulmonary diseases(AECOPD)of A-PACHEⅡ score.Methods 45 patients with AECOPD treated with mechanical ventilation and successful ventilator weaning were selected.In APACHEⅡ<20 patients,13 cases with doxo-fylline by continuous pump were in continuous pump group and 11cases in intravenous drip group;In APACHEⅡ≥20 patients,there were doxofylline by continuous pump with 11 cases and Doxo-fylline by intravenous drip with 10 cases,the effect of ventilator weaning time in different A-PACHEⅡscore between doxofylline by continuous pump and intravenous drip were observed.Re-sults The ventilator weaning time of doxofylline by continuous pump and intravenous drip were compared in APACHEⅡ<20,which was statistically significant difference (P <0.05).but there was no significant difference in APACHEⅡ≥20(P >0.05).Conclusion Ventilator weaning time of AECOPD is influenced by APACHEⅡ score.Continuous pump into doxofylline can obvi-ously relieve mechanical ventilation time in APACHEⅡ<20 and improve the rate of weaning time.