Abstract: Objective To investigate effect of bile acid and liver enzyme index on prognosis of neonates in intrahepatic cholestasis of pregnancy (ICP).Methods 35 pregnant patients with in-trahepatic cholestasis were as the observation group,and the relationship between ICP pregnant women,total bile acid (TBA),alanine aminotransferase (ALT),aspartate aminotransferase (AST),gestational age,newborn meconium-staining amniotic fluid and bile acid,the birth of ges-tational age,birth weight,meconium stained amniotic fluid and neonatal asphyxia were analyzed. 60 normal pregnant women during the same period were selected as control group,and the data of the two groups were comparative analyzed.Results In the observation group,TBA,ALT and AST in pregnant women were significantly higher than that in the control group,the difference was significant (P <0.05);Gestational age and body weight in the observation group was significantly lower than that in the control group,which showed statistically significant (P <0.05);Meconium stained amniotic fluid rate,the rate of neonatal asphyxia,fetal distress in the observation group was significantly higher than that in control group ,so the difference was statistically significant (P <0.05).Conclusion The increased bile acid and liver enzymes in ICP pregnancy women may be the main cause of fetal hypoxia and bad prognosis of neonates,so it should be actively controlled.