Abstract: Objective To conduct a relevance analysis of blood free fatty acid (FFA),uric acid (UA)and testosterone (TTE)with C peptide in male patients with incipient type 2 diabetes mellitus (T2DM).Methods A total of 41 patients with incipient T2DM in outpatient or hospital-ized in our hospital were selected to detect the relevance between relevant indexes and C peptide. Results Serum C peptide was in positive relation with ages,body mass index (BMI),UA level, fasting insulin,FFA,homeostasis model assessment of Insulin Resistance (HOMA-IR)and home-ostasis model assessment-B (HOMA-B)and in reverse connection with glycated hemoglobin,but in no relationship with TTE.Additionally,the multiple linear regression analysis showed that UA was an independent risk factor for C peptide.Conclusion Serum C peptide is in close association with ages,obesity,UA,FFA and glycated hemoglobin and its independent risk factor is Hyperuricemia, which has no correlation with TTE in male patients with incipient T2DM.