Abstract: Objective To explore the perioperative nursing of holmium laser enucleation of the prostate (HoLEP).Methods 45 patients with benign prostatic hyperplasia (BPH)and blad-der outlet obstruction (BOO)underwent holmium laser enucleation of the prostate.The nursing focused on psychological care and preoperative preparation,monitoring postoperative vital signs, the bladder flush unobstructed,preventing of lower limb venous thrombosis,telling patients drink water early according to the bowel sounds,postoperative health guidance and discharge guidance. Results 45 patients who underwent HoLEP had no complications,less postoperative bleeding and discharged from hospital successfully.Conclusion Preoperative psychological nursing for patients with hyperplasia of prostate,preoperative preparation,assisting postoperative bed,monitoring vi-tal signs,guaranteeing the bladder flush unobstructed,taking nursing measures to prevent the vein thrombosis of lower limbs according to DVT score,and skin care,postoperative rehabilitation exer-cise,health guidance and discharge guidance ensure the recovery and discharge from hospital.So it is worthy of promotion.