Abstract: Objective To investigate the application effect of the clinical nursing pathway in improving the life quality of peritoneal dialysis patients in tropical areas of Hainan during treat-ment.Methods 60 peritoneal dialysis patients were randomly divided into observation group and control group.The control group was used traditional nursing mode while the observation group was given clinical nursing pathway.Nursing effects were compared between the two groups.Re-sults Chronic renal failure of peritoneal dialysis,diet and health knowledge score in the observa-tion group was higher than that in the control group.Compliance behavior was better than that in the control group,so the difference was statistically significant (P <0.05).The complications in the observation group were less than those in the control group,the life quality in physical func-tion,role function and social function was higher than that in the control group,the hospitalization time was shorter than that in the control group,and nursing satisfaction was higher than that in the control group,which revealed that the difference was statistically significant (P <0.05).Con-clusion Clinical nursing pathway is a normalized and programmed nursing that can effectively im-prove the nursing quality,reduce the complications of peritoneal dialysis patients and improve the life quality.