Abstract: 、Objective To evaluate the efficacy of evidence-based nursing pathway in usage of amiodarone in peripheral vein.Methods 160 patients used amiodarone were randomly divided into control group and experimental group.The occurrence rate、degree of phlebitis、awareness rate about the drug and satisfaction of nursing were compared.Results In the experimental group、both the incidence rate and degree of phlebitis were significantly lower than that of the con-trol group.On the contrary、the patients、awareness and knowledge of the drug and their satisfac-tion on nursing in the experimental group were significantly higher than that of the control group. Conclusion Evidence-based nursing pathway could regulate the behavior of nurses、and make nursing modeled、processed and specified to reduce the adverse effect、ensure accuracy of work and improve satisfaction of patients.