Abstract: Objective To explore the clinical and pathologic features of gastric in children with bile reflux gastritis (BRG).Methods Clinical materials of 67 children with BRG(the obser-vation group)were analyzed.70 children with chronic gastritis were designed as the control group. Hp infection rate was compared between two groups,and the relationship between the Hp infection and BRG was analyzed.Results The observation group was expressed as fasting or nocturnal wors-ening irregular pain in cullen or upper abdominal,and 43 cases(64.2%)were concomitant with bloating,28 cases (41.8%)with morning mouth bitter,18 cases (26.9%)with acid reflux or vomiting,4 cases (6.0%)with the substernum or below the xiphoid burning sensation.Lake stained mucus,bile spots,pyloric relaxation or remain open,bile reflux were observed by gas-troscopy in 67 children in the observation group,and 17 cases (16.8%)with duodenal inflamma-tion,6 cases (9.0%)with duodenal ulcer,2 cases (4.8%)with gastric ulcer.Pathological exami-nation revealed inflammation were 2 degree in 21 cases in the observation group,other related indi-cators were among 0 to 1 grade,but no glandular atrophy.The Hp infection rate was 23.9%(16 /67)in the observation group,which was significanty lower than 70.0%(49 /70)in the control group(P <0.01),but there was no significant difference among children with varying degrees of disease in the observation group(P >0.05).Conclusion Fasting or nocturnal worsening irregular pain in cullen or upper abdominal are the main clinical features in children with BRG.Jaundice mucus lake,bile spots,pyloric relaxation or remain open,bile reflux can be observed by en-doscopy,and pathologic expressions are mild to moderate mucosal inflammation,but without glandular atrophy,and there is no obvious correlation with Hp infection.