Abstract: Objective To explore efficacy of laparoscopic radical operation for gastric cancer and analyze its influence on immune function.Methods 86 patients with gastric cancer were ran-domly divided into observation group and control group,43 cases in each group.The control group received conventional open type gastric cancer treatment,while observation group received laparo-scopic radical gastrectomy treatment.Blood loss,the first exhaust time,ambulation time,the fre-quency of use of pain medications,first feeding time and length of stay were compared,and immune function after 10 days of treatment(CD3,CD4,CD8,CD4 /CD8 levels and the percentage of NK cells)as well as the incidence rate of postoperative complications were compared.Results Intraop-erative blood loss,the first exhaust time,ambulation time,the frequency of pain medications,first feeding time and hospital stay in the observation group were significantly better than the control group (P <0.05 ).10 days after treatment,CD3,CD4,CD8,CD4 /CD8 levels in both groups sig-nificantly reduced,and of which in the observation group were significantly better than the control group (P <0.05).There was no significant difference of complications between two groups (P <0.05).Conclusion Laparoscopic radical operation for gastric cancer can significantly improve post-operative recovery,reduce incidence of complications and cause less influence on immune function, so it is worthy of clinical application.