Abstract: Objective To explore the short-term efficacy and toxic and adverse responses of paclitaxel concomitant with Tegafur Gimeracil Oteracil Potassium Capsule in the treatment of pa-tients with advanced gastric carcinoma.Methods Paclitaxel concomitant with Tegafur Gimeracil Oteracil Potassium Capsule were given to 36 elderly patients diagnosed with advanced gastric carci-noma so as to evaluate the clinical efficacy and toxic and adverse responses.Results All patients were available to evaluate the clinical efficacy and toxic and adverse responses,with response rate, disease control rate and medium survival time being 44.4%,80.6% and 9.2 months.The main ad-verse responses were myelosuppression and gastrointestinal responses in degree Ⅰ~Ⅱ.Conclusion Paclitaxel concomitant with Tegafur Gimeracil Oteracil Potassium Capsule have certain efficacy with slight toxic and adverse responses and favorable tolerance,becoming one of the optimal choices in treating elderly patients with advanced gastric carcinoma.