Abstract: Objective To explore the effect of focused ultrasound on treatment of patients with vulvar non-neoplastic epithelial disorders.Methods 100 patients with vulvar non-neoplastic epithelial disorders were randomly divided into control group and experimental group.Control group was treated with conservative drug,while experimental group was treated with focused ultrasound. Clinic effect was compared between two groups.Results After treatment,the total effective rate of experimental group was 100.00%,which was significant higher than 70.00% of control group;the recurrence rate of experimental group was 8.00%,which was significant lower than 50.00% of control group (P <0.05).Conclusion Application of focused ultrasound in treatment of patients with vulvar non-neoplastic epithelial disorders can effectively improve the syndrome of patients,and it is safe and reliable.