脱氢表雄酮对卵巢储备低下患者体外受精-胚胎移植的影响

Effect of dehidroepiandroszteron on diminished ovarian reserve patients with in vitro fertilization and embryo transfer

摘要: 目的：观察脱氢表雄酮（DHEA）对卵巢储备功能下降（DOR）患者的影响。方法选取21例有≥1次体外受精-胚胎移植（IVF-ET）失败经历，口服75 mg /d DHEA 3个月后再次行 IVF-ET 治疗的 DOR 患者，比较口服 DHEA 前后 IVF-ET周期相关指标变化情况。结果 DHEA 降低了患者基础卵泡刺激素（FSH）和雌二醇（E2），增加了基础双侧窦卵泡数（AFC）；改善了控制性超促排卵（COH）周期的相关指标；提高了 IVF-ET 妊娠率，降低了流产率。结论 DHEA 改善了 DOR 患者卵巢反应性，有助于 IVF-ET 临床结局的提升。

Abstract: Objective To observe the effect of dehidroepiandroszteron (DHEA)on dimin-ished ovarian reserve (DOR)patients with failed in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 21 patients with ≥1 time of failed IVF-ET were orally administered with 75 mg /d DHEA for 3 months,and IVF-ET was performed again.Relevant indexes in IVF-ET cy-cle before and after oral administration of DHEA were compared.Results DHEA reduced the basic follicle stimulating hormone (FSH)and estradiol (E2)levels,increase basic bilateral antral follicle count (AFC)account,improve relevant indexes in controlled ovarian hyperstimulation (COH)cy-cle,promote pregnant rate in IVF-ET and reduce abortion rate.Conclusion DHEA can effectively improve ovarian response and clinical outcome of IVF-ET for DOR patients.