Influence of high maintenance clopidogrelin on levels of platelet aggregation and hs-CRP in patients with acute myocardial infarction after PCI
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摘要: 目的：探讨高维持剂量氯吡格雷对急性心肌梗死患者 PCI 术后血小板聚集率和 hs-CRP 水平的影响。方法将本院收治的78例接受 PCI 治疗的急性心肌梗死患者随机分为两组，对照组予常规维持剂量（75 mg /d）氯吡格雷，观察组予高维持剂量（150 mg /d）氯吡格雷，比较两组患者 PCI 术前及术后14 d 血小板聚集率和 hs-CRP 水平，并比较主要心血管事件及出血发生率。结果两组患者 PCI 术前血小板聚集率及血清 hs-CRP 水平比较差异无统计学意义（P ＞0．05），但术后血小板聚集率及血清 hs-CRP 水平与术前比较均有明显下降（P ＜0．05），且观察组水平明显低于对照组（P ＜0．05）；观察组与对照组主要终点事件发生率及轻微出血发生率比较均无显著差异（P ＞0．05）。结论采用高维持剂量（150 mg /d）氯吡格雷可进一步增强急性心肌梗死患者 PCI 术后抗血小板聚集的作用及并进一步减轻患者的炎症反应。Abstract: Objective To investigate the influence of high maintenance clopidogrel on levels of platelet aggregation and hs-CRP in patients with acute myocardial infarction after PCI.Methods 78 patients with acute myocardial infarction after PCI were randomly divided into two groups. The control group was treated with routine maintenance dose (75 mg /d)of clopidogrel ,and the ob-servation group was treated with 150 mg /d.Platelet aggregation and hs-CRP levels before treatment and the occurrence of major cardiovascular events and bleeding rate were compared.Results There were no significant differences in platelet aggregation and serum hs-CRP level between the two groups before PCI(P >0.05),but which significantly reduced after operation (P <0.05),and the observation group was significantly lower than the control group (P <0.05).There were no signifi-cant differences in the primary endpoint event rate and minor bleeding rate between two groups(P >0.05).Conclusion The high maintenance dose of clopidogrelin (150 mg /d)can enhance the ef-fect of anti-platelet aggregation and reduce the patients’inflammatory response.
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