Abstract: Objective To study the effect of grouping nursing system of nursing quality and satisfaction in patients with craniocerebral surgery.Methods Nursing staff were divided into three groups,each nursing group set up a leader,3 responsible nurses and 2 assistant nurses and corresponding task distributed to them according to working ability.Nursing quality and satisfac-tion before and after grouping nursing system were compared.Results After grouping nursing, quality score in nursing system,ward management,critical nursing,specialized nursing,basic nursing,sterilization,isolation and nursing documentation were significantly higher than that nurs-ing before.Service attitude,health education,communication,technology and patrol satisfaction was significantly higher that that before nursing(P <0.05 or P <0.01).Conclusion Grouping nursing system helps to improve nursing quality and satisfaction of craniocerebral surgery patients, so it is worthy of clinical application.