Abstract: Objective To explore the effect of enternal nutrition on the radiotherapy of na-sopharyngeal carcinoma patients after percutaneous endoscopic gastrostomy(PEG).Methods 31 nasopharyngeal carcinoma patients were the research objects in the research.There were 12 patients with enteral nutrition therapy and 19 patients with parenteral nutrition therapy.Body mass index (BMI),hemoglobin (Hb),serum albumin protein (ALB),serum total protein (TP)and lympho-cyte count (LYM),PS score and complications after radiotherapy with two methods were com-pared.Results The difference was statistically significant in total protein and albumin in the com-parison group before and after radiotherapy.Intestinal serum,hemoglobin,body mass index , lymph node cell count,PS score remained stable during radiotherapy in the enternal group;Body mass index,PS assessment decreased serum total protein,albumin,hemoglobin,body mass index, lymph node cell counts remained stable in the parenteral group before and after radiotherapy.There was no patients with intestinal complications in enternal group and 7 patients had complications in the parenteral group.Conclusion PEG is reasonable and effective method for nasopharyngeal carci-noma radiotherapy patients combined with oral mucositis.Nutritional support enjoys lower price and less complications,so it is worthy of clinical application.