Abstract: Objective To further explore the function mechanism of stellate ganglion block (SGB)on hormone level in rats with breast hyperplasia.Methods A total of 40 female rats were divided into four groups randomly:blank control group,model group (with breast hyperplasia), treatment group (with Rubixiao)and combined group (Rupixiao combined with SGB).The diame-ter of breast,the height of papilla,the levels of estradiol (E2 ),progesterone (P)and prolactin (PRL)were compared between two groups.Results The difference was significant in the de-creased level of E2 and PRL as well as increased P level between combined group and treatment group (P <0.05).Conclusion In the intervention of rats with breast hyperplasia,combined appli-cation of SGB can effectively regulate the hormone level and reduce the diameter of breast and the height of papilla so as to achieve more superior efficacy.