Abstract: Objective To investigate the changes of blood lipid in the patients with multiple myeloma (MM)and the relationship with clinical stage.Methods 112 initially-diagnosed patients with MM and 80 healthy people were respectively as MM group and normal control group.The lev-els of blood lipid before chemotherapy in two groups and MM patients with different clinical stages as well as the levels before and after chemotherapy were compared.Triglyceride (TG),total choles-terol (TC),high density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C)were included.Results Before chemotherapy,the levels of TC,HDL-C and LDL-C in MM group were significantly lower than that in normal control group,but the difference was not significant compared with TG levels.The levels of TC,HDL-C and LDL-C in phase Ⅲ and LDL-C in phase Ⅱ were all significantly lower than that in normal control group,and the difference was not significant compared with the levels of blood lipid in phase Ⅰ.After 2 courses of chemotherapy,the levels of TC and HDL-C in effectively treated patients were obviously higher than that before chemotherapy.Conclusion The level of blood lipid is helpful to diagnose patients with MM and to evaluate the clinical staging and prognosis.