Abstract: Objective To explore the risk factors of hypoglycemia in elderly diabetic pa-tients during hospitalization.Methods Clinical material of 76 patients with diabetes was retrospec-tive analyzed.41 diabetic patients with hypoglycemia were in observation group while the other 35 diabetic patients without hypoglycemia were in control group.Results The percentage of drinking of patients in the observation group were significantly higher than that in the control group (χ2=8.280,P =0.004).The ratio of patients with application of Beta blocker,the proportion of pa-tients with a variety of thiourea drugs,replacement of antidiabetic drugs,the proportion of patients with irregular diet and excessive movement in the observation group were significantly higher than that in the control group (P <0.05).At the time of admission,level of blood urea nitrogen, serum creatinine,blood urea and serum alanine aminotransferase in the observation group were sig-nificantly higher than that in the control group (P <0.05).Logistic regression analysis showed that abnormal liver function,mixture application of beta blocker,a variety of thiourea drugs,alco-hol and replacement of hypoglycemic drugs were the independent risk factors to cause hypoglycemia in elderly diabetic patients during hospitalization (P <0.05).Conclusion Hypoglycemia could occur in elderly diabetic patients during hospitalization,and improper treatment and bad habits may affect the occurrence of hypoglycemia.