Abstract: Objective To study The effect of anti-depression treatment on endothelial function of coronary artery disease (CAD)and depressive disorder.Methods 120 CAD patients with depressive disorder treated in our hospital from September 2007 to February 2009 were ran-domized to control group (n =58)and treatment group (n =62).The patients in both groups were given conventional treatment and psychological intervention,and the patients in treatment group were added 20 mg Citalopram tablets every night.Scores of Hamilton Depression Rating Scale(HAMD)of the patients were measured and endothelial function of the patients were evaluated at 8 weeks before and after the treatment.Results After 8 week treatment,the HAMD score was (7.60±3.49)in treatment group and (20.58±3.20)in control group,the difference was signifi-cant after comparison of two groups (P <0.01).The values of FMD% were respectively (4.69± 0.58)in treatment group and (4.45±0.69)in control group which revealed that the difference was significant (P <0.05).Conclusion Citalopram can significantly improve depression and en-dothelial function of CAD patients with depression.