Abstract: Objective To explore the influence of nifedipine controlled release tablets com-bined with indapamide on renal function of elderly patients with refractory isolated systolic hyper-tension.Methods 96 elderly patients with isolated systolic hypertension were randomly divided in-to two groups according to the admission odd and even day,48 cases in each group.Control group was treated with nifedipine controlled release tablets,while the observation group was treated with nifedipine controlled release tablets combined with indapamide on the basis of control group.Result After treatment,blood pressure in both groups decreased,and decreasing range of blood pressure in observation group was significantly greater than the control group(P <0.05).There were signif-icant differences of serum creatinine,creatinine clearance rate and microalbuminuria detection result before and after treatment in observation group (P <0.05).Conclusion Nifedipine controlled re-lease tablets combined with indapamide can effectively reduce blood pressure and promote renal func-tion in elderly patients with refractory isolated systolic hypertension,so it is worthy of clinical popu-larization.