Abstract: Objective To explore the clinical effect of small bone flap craniotomy combined with microsurgery on treatment of hypertensive cerebral hemorrhage in basal ganglia region.Meth-ods 38 patients with hypertensive cerebral hemorrhage in basal ganglia region (medium volume of hematoma,30~60 mL)were randomly divided into two groups.Microsurgery group was treated with small bone flap craniotomy combined with microsurgery,while the control group was treated with small bone flap craniotomy.A prognosis was compared between two groups half a year after treatment.Results ADL score was (78 ±15)in microsurgery group,which was significantly higher than (50±19)in control group.Conclusion Small bone flap craniotomy combined with microsurgery is more effective than normal surgery in treating patients with medium hematoma vol-ume of hypertensive cerebral hemorrhage in basal ganglia region.