Abstract: Objective To explore the efficacy and safety of laparoscopic combination thera-py of choledochoscope and plasma lithotripsy in treatment of patients with hepatolithiasis.Methods 28 hepatolithiasis patients treated with laparoscopic combination therapy of choledochoscope and plasma lithotripsy were collected and designed as observation group,and 28 28 hepatolithiasis pa-tients treated with open surgical therapy were collected and designed as control group.The major perioperative and postoperative T-tube monitoring indicators as well as residual stone rate were compared between two groups.Results The blood loss,postoperative exhaust time and hospital stay in the observation group were significantly less and shorter than those in the control group (P<0.05).The T-tube drainage and duct pressure in the observation group from the third day af-ter operation were significantly less than the control group (P <0.05).Residual stone rate in ob-servation group was 92.86 %,which was significantly higher than 78.57% in the control group (P < 0.05 ).Conclusion Laparoscopic combination therapy of choledochoscope and plasma lithotripsy shows a series of advantages such as intuitive,minimally invasive,low residual stone rate and safety in treatment of hepatolithiasis,so it is worthy of clinical application and populariza-tion.