Abstract: Objective To explore the clinical effect of transurethral resection combined with intravesical mitomycin perfusionon in the treatment of cyslitis glandular (CG).Methods A total of 70 patients with CG in our hospital were randomly divided into control group (n =35)and obser-vation group (n =35).After transurethral resection,the control group was given pirarubicin hy-drochloride by perfusion of bladder,while the observation given pirarubicin hydrochloride combined with mitomycin by perfusion of bladder.The quality of life was evaluated by Quality of Life Scale in both groups,and clinical effects were compared.Results The difference was not significant though the overall response rate in observation group was slightly higher than that in the control group;The score of different items of quality of life in the obeservation group was evidently higher,but the inci-dence of adverse reactions was markedly lower in the observation group than that in the control group,and the differences was statistical significant.Conclusion Transurethral resection combined with intravesical mitomycin perfusion is effective in treating CG with low incidence of adverse reac-tions and high quality of life for patients,so it is worthy of being widely promoted in clinic.