Abstract: Objective To observe and analyze the effects of rehabilitation training com-bined with drugs in prevention from secondary osteoporosis patients with hemiplegia caused by stroke.Methods 120 patients with hemiplegia caused by stroke were randomly divided into obser-vation group and control group with 60 patients in each group.The patients in the control group were treated with rehabilitation training on the basis of the conventional therapy,while the pa-tients in the observation group were treated with the combined anti-osteoporosis drugs including salmon calcitonin and calcium carbonate vitamin D3 tablets based on the therapy of the control group.The bone density of femur proximal Ward River,distal radius,first lumbar spine at hemi-plegia side of research time,the first month and the third month after the treatment in the two groups were detected and compared.Results There were no significant differences in bone density of the three tested sites of patients at the research time between the two groups (P >0.05),while at the first month and the third month after the treatment,the bone density of the patients in the observation group at the three sites were significantly higher than those in the control group (P <0.05).Conclusions The combined application of drugs and rehabilitation training to the patients with post-stroke hemiplegia can gain significant effect in prevention from the osteoporosis.