Abstract: Objectives To observe and analyze the efficacy and safety of the different opera-tion methods in the treatment of hard nucleus cataract after glaucoma surgery.Methods 100 pa-tients with hard nucleus cataract after glaucoma operation were selected.According to the different treatment methods,the patients were divided into the observation group (n =54,75 eyes)and the control group (n =46,61 eyes).The observation group was treated with manual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision,while the control group was treated with the phacoemulsification through clarity corneal incision.All the patients were followed up for 3 to 6 months.Changes of visual acuity,the depth of anterior chamber,intraocular pressure and corneal endothelial cell counting before and after operation as well as the adverse reactions were observed and compared.Results Compared with visual acuity before treatment,the visual acuity of the patients in both groups improved significantly after treatment(P <0.05).The anterior chamber depth grades of patients in both groups were significantly higher than those before treat-ment (P <0.05),and after treatment,the anterior chamber depth grade of the patients in the observation group was significantly better than that in the control group (P <0.05).There was no significant difference of intraocular pressure before and after the treatment in both groups (P>0.05).The corneal endothelial cell density of the patients in the observation group decreased (P >0.05),while that in the control group decreased significantly (P <0.05).The corneal en-dothelial cell density of the patients in the observation group after the corneal endothelium was significantly higher than that in the control group (P <0.05).The incidence rates of adverse re-action in the two groups were 21.33%(16 /75)and 21.31%(13 /61)respectively,and the symp-tom were controlled and cured after the symptomatic treatment.Conclusion Application of man-ual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision for the patients with hard nucleus cataract after glaucoma surgery can effectively improve the visual acuity and anterior chamber depth of the patients.It is safe and better than ultrasonic emulsification nu-cleus surgery in the aspects of improving anterior chamber depth and reducing the injury to corneal cells.It is worthy of clinical application.