Abstract: Objective To explore the influence of target controlled infusion (TCI)on physi-cal sign and immunologic function of the patients with radical resection of rectal carcinoma.Methods Post-anesthetic physical sign,levels of IL-6 and TNF-αand change of Tregs in 26 patients with radical resection of rectal carcinoma were analyzed.Results There were significant differences of every index of physical sign and levels of IL-6 and TNF-αin patients between intraoperative period and preoperative and one hour after operation (P <0.05).There was significant difference of level of Tregs between intraoperative period and preoperative period(P <0.05).Conclusion TCI shows a certain influence on physical sign of patients,and each index of physical sign should be monitored carefully in order to avoid the incidence of complications.Meanwhile,it shows a short-term influ-ence on the immune function as well,but depending on rapid recovery,this influence won′t cause a long-term decline of immune function.