Abstract: Objective To explore the influence of simvastatin combined with clopidogrel on prognosis and levels of IL-6 and hs-CRP CRP in patients with unstable angina pectoris (UAP). Methods 105 patients with UAP from January 2011 to January 2013 were randomly divided into observation group (n =53)and control group (n =52).On the basis of conventional treatment, control group was treated with clopidogrel,while observation group was treated with simvastatin plus clopidogrel.Clinical efficacy,levels of IL-6 and hs-CRP and cardiovascular events were com-pared between two groups.Results The total effective rate was 59.6% in the control group, which was significantly lower than 86.8% in the observation group (P <0.01).After treatment, levels of IL-6 and hs-CRP decreased significantly in both groups (P <0.05),and there were signifi-cant differences between two groups (P <0.05).All the patients were followed up for 30 days,and there were significant differences in aspect of incidence of postoperative angina and myocardial in-farction between two groups (P <0.05).Conclusion Calcium clopidogrel combined with simvas-tatin can effectively improve levels of IL-6 and hs-CRP in the treatment of patients with UAP.