Abstract: Objective To explore the repair effect of mouse nerve growth factor (mNGF) on the neurological function of hand-foot-and-mouth disease (HFMD)children with central lesion. Methods 86 children with severe HFMD were divided into treatment group and control group ac-cording to the number of hospitalization,43 cases in each group.Both groups were treated with conventional comprehensive treatment for HFMD,while the treatment group was injected with mNGF on the basis of basic treatment.The disappearance time of symptoms associated with nervous system injury,neurological scores before treatment and on the third,seventh days of treatment as well as the levels of while cells and creatine kinase (CK)before and after treatment were compared, and the adverse reactions were observed.Results The disappearance time of vomiting,skittishness, limb shaking,myasthenia and somnolence as well as hospital stay in the treatment group were sig-nificantly shorter than those in the control group.Neurological scores on the third,seventh days of treatment decreased significantly in both groups,and neurological scores in treatment group were significantly lower than control group.After treatment,the levels of white cells and CK decreased significantly in both groups,and the decreased range in treatment group was larger.No obvious ab-normal reactions were observed by liver and kidney examination during treatment.Conclusion For children with HFMD and central lesion,application of mNGFcan effectively promote the repairmen of injured nervous tissue,improve the neurological function and shorten the course of disease.