脑卒中后抑郁的研究进展

胡颉, 郭海英

胡颉, 郭海英. 脑卒中后抑郁的研究进展[J]. 实用临床医药杂志, 2014, (1): 143-146. DOI: 10.7619/jcmp.201401048
引用本文: 胡颉, 郭海英. 脑卒中后抑郁的研究进展[J]. 实用临床医药杂志, 2014, (1): 143-146. DOI: 10.7619/jcmp.201401048

脑卒中后抑郁的研究进展

详细信息
  • 中图分类号: R743.3

  • 摘要: 卒中后抑郁(PSD)是中风后最常见的神经精神性并发症,至少1/3的患者在中风发作一段时间后表现出情绪症状[1,5],如焦虑、绝望及快感缺乏,严重影响患者中风后机体功能的恢复.PSD临床进展较为缓慢,但易引起一系列的健康问题,近年来该病的发病率和死亡率也有所增加[2].34%的老年患者急性卒中后,抑郁症在20个月后仍然存在[3],并因此造成认知和机体功能的恶化.有研究显示PSD的发生仅仅与卒中后患者产生的各方面心理压力有关[4].PSD的主要生物学理论是胺假说,很可能是缺血性病变导致生物胺的生物利用度降低,如5-羟色胺(5-HT)、多巴胺(DA)和去甲肾上腺素(NE);此外,乙酰胆碱也可受累.本研究探讨PSD动物模型、PSD潜在的相关机制(包括海马神经新生、神经营养因子信号及神经递质)及临床主要干预方法的相关机制.
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出版历程
  • 发布日期:  2014-07-09

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