核黄素磷酸钠治疗多西他赛化疗后口腔溃疡的疗效分析

陈丹, 何肇晴

陈丹, 何肇晴. 核黄素磷酸钠治疗多西他赛化疗后口腔溃疡的疗效分析[J]. 实用临床医药杂志, 2013, (21): 131-133,136. DOI: 10.7619/jcmp.201321039
引用本文: 陈丹, 何肇晴. 核黄素磷酸钠治疗多西他赛化疗后口腔溃疡的疗效分析[J]. 实用临床医药杂志, 2013, (21): 131-133,136. DOI: 10.7619/jcmp.201321039
CHEN Dan, HE Zhaoqing. Analysis of therapeutic effect of riboflavin sodium phosphate in the treatment of oral ulcers induced by docetaxel-based chemotherapy[J]. Journal of Clinical Medicine in Practice, 2013, (21): 131-133,136. DOI: 10.7619/jcmp.201321039
Citation: CHEN Dan, HE Zhaoqing. Analysis of therapeutic effect of riboflavin sodium phosphate in the treatment of oral ulcers induced by docetaxel-based chemotherapy[J]. Journal of Clinical Medicine in Practice, 2013, (21): 131-133,136. DOI: 10.7619/jcmp.201321039

核黄素磷酸钠治疗多西他赛化疗后口腔溃疡的疗效分析

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R632.1

Analysis of therapeutic effect of riboflavin sodium phosphate in the treatment of oral ulcers induced by docetaxel-based chemotherapy

  • 摘要: 目的 观察核黄素磷酸钠治疗恶性肿瘤患者行多西他赛化疗后所致口腔溃疡的临床疗效.方法 将120例以多西他赛为主要化疗药物行全身化疗的恶性肿瘤患者随机分为2组,每组60例.全身化疗前24h,2组均给予地塞米松,治疗组在此基础上给予核黄素磷酸钠静脉滴注至化疗结束,观察化疗后患者的摄食量、第6及第8天的白细胞计数、口腔溃疡程度及溃疡恢复时间.结果 治疗组患者出现摄食量明显下降及拒食的比例显著低于对照组,差异有统计学意义;治疗组化疗后第6天白细胞计数Ⅰ、Ⅱ度比例显著高于对照组,但Ⅲ、Ⅳ度比例明显低于对照组,而2组化疗后第8天白细胞计数比较无显著差异;治疗组Ⅰ~Ⅳ度口腔溃疡发生率均有低于对照组的趋势,且溃疡愈合时间明显短于对照组,差异有统计学意义.结论 核黄素磷酸钠治疗恶性肿瘤患者行多西他赛化疗后所致的口腔溃疡临床疗效确切,不仅可防止患者出现摄食量明显下降,还对骨髓抑制有一定保护作用.
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出版历程
  • 发布日期:  2014-04-07

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