PECAM-1和hs-CRP水平变化与老年慢性左心力衰竭严重程度相关性的研究

The relationship between various degrees of chronic left heart failure and changes of circulating platelet endothelial cell adhesion molecule-1 and high-sensitivity C-reactive protein in elderly patients

摘要: 目的探讨血小板内皮细胞黏附分子-1(platelet endothelial cell adhesion molecule-1,PECAM-1)和高敏C反应蛋白(hs-CRP)水平变化与老年慢性左心力衰竭严重程度的相关性.方法根据NYHA心功能分级和左心室射血分数(LVEF)将健康对照者和老年慢性左心力衰竭患者分为对照组LVEF(63.97.0±4.65)%、Ⅰ级组LVEF(42.67±2.06)%、Ⅱ级组LVEF(34.26±3.17)%、Ⅲ级组LVEF(29.05±1.07)%和Ⅳ级组LVEF(25.17±1.42)%.采用流式细胞仪检测健康对照者和老年慢性左心力衰竭患者PECAM-1的表达.应用散射免疫比浊法测定hs-CRP的水平.结果随着NYHA心功能分级的升高和LVEF的下降,PECAM-1和hs-CRP的水平明显上升.结论 PECAM-1和hs-CRP的水平显著升高可能参与了老年慢性左心力衰竭发生发展的机制.